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<P class="p0 ft0">Professor Mike Holcombe</P>
<P class="p1 ft2">Director of the Advanced Computing Research Centre (<A href="http://www.acrc.com"><SPAN class="ft1">ACRC</SPAN></A>)</P>
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<P class="p2 ft3">The BioIncubator, home of the ACRC.</P>
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<P class="p3 ft4">The ACRC is an <NOBR>industry-facing</NOBR> research centre with expertise in Big data analytics; Software testing and QA; and <NOBR>Large-scale</NOBR> Simulation.</P>
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<P class="p4 ft5">Research in Computational Biology:</P>
<P class="p5 ft7">using <NOBR>agent-based</NOBR> modelling and the <A href="http://www.flame.ac.uk"><SPAN class="ft6">FLAME </SPAN></A>framework</P>
<P class="p6 ft8">Innate immune system - the role of <NOBR>NFkappa-B</NOBR></P>
<P class="p7 ft9">How the actin cytoskeleton helps to control responses to infection.</P>
<P class="p8 ft9">What effect do key <NOBR>co-receptors</NOBR> such as TILLR have on the process?</P>
<P class="p1 ft8">Oxygen processing in E. coli</P>
<P class="p9 ft10">The role of FNR in the management of oxygen and the transition between aerobic and</P>
<P class="p10 ft8">The <NOBR>blood-brain</NOBR> barrier - how does it work?</P>
<P class="p11 ft10">Detailed simulation of blood flow in capillaries and how nano particles interact with receptors</P>
<P class="p12 ft11">MapKinase is involved in many, often conflicting, processes. how does this work?</P>
<P class="p13 ft9">The EURACE model of the European Economy is one of the largest and most detailed models ever built.</P>
<P class="p14 ft8">See: <A href="http://eurace.group.shef.ac.uk"><SPAN class="ft12">http://eurace.group.shef.ac.uk</SPAN></A></P>
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<P class="p2 ft13">Agile development - textbook</P>
<P class="p15 ft15">Running an Agile Software Development Project, <SPAN class="ft14">Published by Wiley</SPAN>.</P>
<P class="p16 ft13">See: <NOBR><A href="http://agile.genesys-solutions.org.uk"><SPAN class="ft16">http://agile.genesys-solutions.org.uk</SPAN></A></NOBR></P>
<P class="p17 ft8">actin simulation</P>
<P class="p18 ft8">E.coli simulation</P>
<P class="p19 ft17">Blood brain barrier</P>
<P class="p20 ft12"><A href="http://www.dcs.shef.ac.uk/~wmlh/RecentPubs.html">Some recent publications</A></P>
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